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Cake day: March 13th, 2023

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  • Almost from the beginning, some transplant doctors had raised concerns that patients on Dr. Reddy’s tacrolimus were faring worse than those on other generics. The Cleveland Clinic was so alarmed that it banned Dr. Reddy’s generic for its transplant patients in 2013. Later, at the Tulane Transplant Institute, doctors found that patients taking generic tacrolimus by any drugmaker had a higher chance of organ rejection, and the hospital decided to use only the brand drug.

    Holly knew none of this when she picked up her daughter’s tacrolimus at the local Kroger grocery store after Hannah’s discharge in the fall of 2019. (Kroger didn’t respond to requests for comment.) Unlike with Hannah’s medical care, where Holly could research and choose a doctor or hospital, the brand of generic tacrolimus Hannah received was out of her hands. She would get whichever one that pharmacy happened to have in stock.

    Inova’s transplant team had typed, in the electronic prescription that it sent to Kroger, “do not dispense Dr. Reddy.” But that’s what Hannah received.



  • IIII for four o’clock but IX for nine o’clock

    Very interesting - I have a newer Timex with RN on my (left) wrist right now and never thought about alternate notations for the numbers. Turns out it uses “IIII” for 4 but “IX” for 9 rather than spelling it all out in additive form. The designers made a curious choice for people wearing the watch on their left - the 9 o’clock “IX” is upside down so that it reads “XI” from the point of view of the wearer rather than, thus it looks like 9 is 11.

    We had to learn RN when I was a kid, and I assume that’s only because there were a few RN clocks remaining out in the world. I’ve never felt like I need to process the numerals on a clock anyway - once you know what position corresponds to what hour you’re good to go. Many clocks and watches don’t have numerals at all and that doesn’t impair most people from using them.