Not universal, for example we use zebrafish for spine defect models since mouse spine has an odd curve/hunch that doesn’t line up as well. But for general metabolism/pathology/embryonic development they do a great job of mimicking human disease under the microscope. Its not always 1:1 but we learn a lot from these little guys.
Not really. What’s the translate rate to humans? 9%?
Mice can model some diseases well, but they are not universally good models.
Not universal, for example we use zebrafish for spine defect models since mouse spine has an odd curve/hunch that doesn’t line up as well. But for general metabolism/pathology/embryonic development they do a great job of mimicking human disease under the microscope. Its not always 1:1 but we learn a lot from these little guys.